Leading into SRS 2018, Medicrea Highlights a New Study Showing That Patients Implanted with UNiD™ Patient-Specific Rods Are 2.6 Times More Likely to Be Optimally Corrected

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LYON, France & NEW YORK–(BUSINESS WIRE)–#AdaptiveSpineIntelligence–The Medicrea® Group (Euronext Growth Paris: FR0004178572 –
ALMED ; OTCQX Best Market – MRNTY & MRNTF), pioneering the
transformation of spinal surgery through Artificial Intelligence,
predictive modeling and patient specific implants with its UNiD™ ASI
(Adaptive Spine Intelligence) proprietary software platform, services
and technologies, announced today the publication of a new study
validating the use of UNiD™ Patient-Specific Rods (PSR) for surgical
correction of sagittal imbalance in adults.

Five years after its initial launch in September 2013, over 2,800
patients have benefited from UNiD™ ASI 100% proprietary pre-operative
planning technologies and services associated with patient-specific
spinal realignment rods, with a strong acceleration in adoption rate in
2018 especially in the USA (+62% cases year-to-date 2018 and +90% in Q3

Since its inception, the technology has supported surgeons specializing
both in adult and pediatric indications with planning services and
patient-specific implants focused on restoring sagittal and coronal

Federico Solla, M.D., Orthopaedic and Scoliosis Surgery Unit, Lenval
Hospital, Nice, France and UNiD™ ASI user recently published the Article
titled “Patient-Specific Rods for Surgical Correction of Sagittal
Imbalance in Adults: Technical Aspects and Preliminary Results”
. In
this article, Federico Solla emphasizes the expected benefits of patient
specific spinal care which include the optimal execution of the plan,
decreased mechanical complications, and reduced operating time, no
longer requiring the bending of rods during surgery.

This study demonstrates that the use of patient specific rods improves
the correspondence between planning and surgical realization.

Evalina Burger, MD, Department of Orthopedics, University of Colorado
SOM, Aurora, CO, co-author, stated that “these results support the use
of the UNiD™ ASI platform to obtain the expected patient-specific
sagittal balance with a special focus on the difference pelvic incidence
(PI) – lumbar lordosis (LL).”

Medicrea’s proprietary UNiD™ ASI technology uses Artificial Intelligence
that digests scientific data to generate intelligent surgical planning
through machine learning while simultaneously allowing the Spine Surgeon
to perform detailed, custom analyses of his cases. The entire clinical workflow
is thus managed
from start to finish through the UNiD™ comprehensive

Christopher Kleck, MD, Department of Orthopedics, University of Colorado
SOM, Aurora, CO, co-author, added “With its proprietary UNiD™ ASI
technology, Medicrea started revolutionizing the spine world by
developing a model taking into consideration compensatory mechanisms to
individually predict each patient’s outcomes.”

By simulating surgical strategies using proprietary data and algorithms
taking into consideration patients’ optimal sagittal alignment and
compensatory mechanisms, Medicrea produces a patient-specific
industrially bent. This process preserves the rod’s full
integrity, and limits stress points that could lead to rod fracture once

Vincent Fiere, MD, Spinal Unit, Santy Orthopaedic Center and Mermoz
Hospital Ramsay GDA, Lyon, France, and co-author, concluded “With
Medicrea’s breakthrough technology, we showed that patients implanted
with UNiD™ PSRs were 2.6 times more likely to be optimally corrected.”

“We are extremely pleased to see an increasing number of publications
focusing on the application of UNiD™ ASI in the treatment of complex
spinal deformities” said Denys Sournac, Founder, Chairman and CEO of
Medicrea. “A month ago, we concluded the first Artificial Intelligence
focused meeting in Lyon with 20 international spine surgeons considered
thought-leaders in their field. Medicrea
Artificial Intelligence and Analytics (MAIA)
was a success. A couple
weeks ago, Jean-Luc Clement, MD, Fondation Lenval, Nice, France,
published an Article
validating our predictive modelling for AIS patients. Today, we are
announcing another publication validating this technology for the adult
population. The revolution is only starting, and we are looking forward
to the surgeon community embracing the UNiD™ ASI technology to provide
their patients with the best possible care.”

here to reach the article: Patient-specific Rods for Surgical Correction
of Sagittal Imbalance in Adults: Technical Aspects and Preliminary
Results – Solla, Federico, MD; Barrey, Cédric Y., MD, PhD; Burger,
Evalina, MD; Kleck, Christopher J., MD; Fière, Vincent, MD

here to reach the article: Surgical increase in thoracic kyphosis
increases unfused lumbar lordosis in selective fusion for thoracic
adolescent idiopathic scoliosis – Jean-Luc Clément, MD; Yann Pelletier,
MD; Federico Solla, MD; Virginie Rampal, MD

here to reach the video: UCSF Clinical Application: Live Pre-Op Planning
with Adaptive Spine Intelligence

here to reach the video: UNiD™ ASI Workflow

here to reach the video: MAIA – Medicrea Artificial Intelligence and
Analytics – 1st Annual Meeting 2018

About Medicrea (www.medicrea.com)

Through the lens of predictive medicine, Medicrea leverages its
proprietary software analysis tools with big data and machine learning
technologies supported by an expansive collection of clinical and
scientific data. The Company is well-placed to streamline the efficiency
of spinal care, reduce procedural complications and limit time spent in
the operating room.

Operating in a $10 billion marketplace, Medicrea is a Small and Medium
sized Enterprise (SME) with 210 employees worldwide, which includes 50
who are based in the U.S. The Company has an ultra-modern manufacturing
facility in Lyon, France housing the development and production of 3D-
printed titanium patient-specific implants.

For further information, please visit: Medicrea.com.

Connect with Medicrea

Medicrea is listed on
EURONEXT Growth Paris
FR 0004178572

Ticker: ALMED

Medicrea is traded on
OTCQX Best Market


Founder, Chairman and CEO
Chief Financial Officer
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